Enthusiasm for solving a business problem they need help with is the quickest way to get a hiring manager's attention. Let's face it, they aren't hiring you for the heck of it.  You need to explain how you can make things better for an employer. By talking about the problems you love

to solve and how you go about solving them, the hiring manager will clearly see the type of employee you are and could be for their company.

The research you conducted on the employer before your interview will come in handy here.  Connect your past accomplishments and problem-solving experience to the current problems you know the company is trying to solve (from your research).

You'll impress the hiring manager with your knowledge of the company and you'll further answer the question, "Tell me about yourself."

Let them know how you hope to grow your skills and abilities by taking your problem-solving skills to the next level.  Also, mention how passionate you are about what the company does and how you feel connected to its mission (echoing what you wrote in your disruptive cover 

letter). This lets the employer know you plan to focus on being successful and expanding your value to the organization if you get hired.